articleNature CommunicationsApr 16, 2025GOLD OA

A clinical benchmark of public self-supervised pathology foundation models

Icahn School of Medicine at Mount Sinai · Sahlgrenska University Hospital · +2 more institutions

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Abstract

The use of self-supervised learning to train pathology foundation models has increased substantially in the past few years. Notably, several models trained on large quantities of clinical data have been made publicly available in recent months. This will significantly enhance scientific research in computational pathology and help bridge the gap between research and clinical deployment. With the increase in availability of public foundation models of different sizes, trained using different algorithms on different datasets, it becomes important to establish a benchmark to compare the performance of such models on a variety of clinically relevant tasks spanning multiple organs and diseases. In this work, we…

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