TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies
Xiamen University · Shenzhen University Health Science Center · +4 more institutions
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor predominantly expressed by microglia in the brain. Recent studies have established TREM2 as a central immune signaling hub in neurodegeneration, where it triggers immune responses upon sensing pathological development and tissue damages. TREM2 binds diverse ligands and activates downstream pathways that regulate microglial phagocytosis, inflammatory responses, and metabolic reprogramming. Interestingly, TREM2 exists both in its membrane-bound form and as a soluble variant (sTREM2), that latter is generated through proteolytic shedding or alternative splicing and can be detected in cerebrospinal fluid and plasma. Emerging…
Citation impact
- FWCI
- 30.98
- Percentile
- 100%
- References
- 144
Authors
5- LZLianshuai ZhangCorresponding
Xiamen University
- XXXianyuan Xiang
Shenzhen University Health Science Center, Shenzhen Institutes of Advanced Technology, Shenzhen Technology University
- YLY. Li
Xiamen University
- GBGuojun Bu
Hong Kong University of Science and Technology
- XCXiao‐Fen Chen
Shenzhen University, Xiamen University
Topics & keywords
- TREM2
- Neurodegeneration
- Microglia
- Immune system
- Neuroscience
- Innate immune system
- Receptor
- Neuroimmunology
- Good health and well-being