Asymmetric amination of alkyl radicals with two minimally different alkyl substituents

Differentiating between similar alkyl groups is a major challenge in asymmetric catalysis. Achieving enantiocontrol over unactivated prochiral alkyl radicals is even more difficult owing to their high reactivity and limited interactions with chiral catalysts. In this study, we report a copper-catalyzed asymmetric amination of unactivated prochiral secondary alkyl radicals, using specifically designed chiral anionic multidentate ligands in a radical substitution reaction. This approach efficiently produces highly enantioenriched α-chiral alkyl amines and facilitates the enantioselective formal synthesis of a series of important drug molecules. Mechanistic studies reveal that bulky peripheral modifications on…