Decoding tumor angiogenesis: pathways, mechanisms, and future directions in anti-cancer strategies
Central South University · Zhuzhou Central Hospital · +2 more institutions
Abstract
Angiogenesis, a crucial process in tumor growth and metastasis, necessitates targeted therapeutic intervention. This review reviews the latest knowledge of anti-angiogenesis targets in tumors, with emphasis on the molecular mechanisms and signaling pathways that regulate this process. We emphasize the tumor microenvironment's role in angiogenesis, examine endothelial cell metabolic changes, and evaluated potential therapeutic strategies targeting the tumor vascular system. At the same time, we analyzed the signaling pathway and molecular mechanism of tumor angiogenesis in detail. In addition, this paper also looks at the development trend of tumor anti-angiogenesis drugs, including their future development…
Citation impact
- FWCI
- 45.03
- Percentile
- 100%
- References
- 306
Authors
8- XLXueru LiuCorresponding
Central South University, Zhuzhou Central Hospital
- JZJuan Zhang
Central South University, Zhuzhou Central Hospital
- TYTing Yi
Central South University, Zhuzhou Central Hospital
- HLHui Li
Central South University, Zhuzhou Central Hospital
- XTXing Tang
Central South University, Zhuzhou Central Hospital
Topics & keywords
- Angiogenesis
- Metastasis
- Medicine
- Tumor microenvironment
- Cancer research
- Cancer
- Signal transduction
- Mechanism (biology)
- Good health and well-being