A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing
Wenzhou Medical University · First Affiliated Hospital of Wenzhou Medical University · +4 more institutions
Abstract
Achieving rapid and scar-free wound repair is a key goal in the field of regenerative medicine. Herein, a dynamically Schiff base-crosslinked hydrogel (F/R gel) with phase-adaptive regulating functions is constructed to integratedly promote rapid re-epithelization with suppressed scars on chronic infected wounds. Specifically, the gel effectively eliminates multidrug-resistant bacterial biofilm at infection stage via antimicrobial activity of ε-polylysine firstly dissociated from hydrogel matrix in infectious microenvironment, and interrupts the severe oxidative stress-inflammation cycle at wound site by the released ceria nanozyme, thus stimulating a pro-regenerative environment to ensure tissue repair.…
Citation impact
- FWCI
- 77.48
- Percentile
- 100%
- References
- 65
Authors
16- FZFan ZhangCorresponding
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Zhejiang Lab, University of Chinese Academy of Sciences
- HZHaijuan Zhang
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Zhejiang Lab
- SWShengfu Wang
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, Zhejiang Lab
- MGMingying Gao
Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University
- KDKui Du
Wenzhou Medical University, Zhejiang Lab
Topics & keywords
- Wound healing
- Ultrashort pulse
- Phase (matter)
- Cell biology
- Chemistry
- Medicine
- Biology
- Immunology