reviewJournal of Experimental & Clinical Cancer ResearchApr 21, 2025GOLD OA

MicroRNA in cancer therapy: breakthroughs and challenges in early clinical applications

MTMaria Teresa Di MartinoPTPierosandro TagliaferriPTPierfrancesco Tassone

Magna Graecia University

PubMed
Indexed incrossrefdoajpubmed

Abstract

MicroRNAs (miRNAs) have emerged as pivotal regulators in cancer biology, influencing tumorigenesis, progression, and resistance to therapy. Their ability to modulate multiple oncogenic and tumor-suppressive pathways positions them as promising therapeutic tools or targets. This review examines the dual role of miRNAs in solid and hematological malignancies, starting from their dysregulation in various cancer types. Therapeutic approaches, including miRNA replacement and inhibition strategies, are discussed alongside innovative delivery systems such as lipid nanoparticles and exosomes. Despite their transformative potential, challenges persist, including off-target effects, immune activation, and delivery…

Citation impact

147
total citations
FWCI
107.34
Percentile
100%
References
101
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • microRNA
  • Microvesicles
  • Cancer
  • Clinical trial
  • Transformative learning
  • Medicine
  • Carcinogenesis
  • Cancer therapy
UN Sustainable Development Goals
  • Good health and well-being
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