articlePNAS NexusMar 27, 2025GOLD OA

Antibiotics in the global river system arising from human consumption

McGill University · Johns Hopkins University · +2 more institutions

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Abstract

The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due to their toxicity and influence on antimicrobial resistance. After human consumption and partial metabolism, antibiotic residues are excreted and undergo complex accumulation and decay processes along their pathway from wastewater to natural river systems. Here, we use a global contaminant fate model to estimate that of the annual human consumption of the 40 most used antibiotics (29,200 tonnes), 8,500 tonnes (29%) are released into the river system and 3,300 tonnes (11%) reach the world's oceans or inland sinks. Even when only domestic sources are considered (i.e. not including veterinary or industrial…

Citation impact

44
total citations
FWCI
17.11
Percentile
100%
References
142
Citations per year

Authors

5

Topics & keywords

Keywords
  • Consumption (sociology)
  • Aquatic ecosystem
  • Antibiotic resistance
  • Ecosystem
  • Water quality
  • Environmental science
  • Antibiotics
  • Surface water
UN Sustainable Development Goals
  • Clean water and sanitation
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