reviewChemical ReviewsApr 22, 2025Closed access

Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Donghua University · Chemical Synthesis Lab · +8 more institutions

PubMed
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Abstract

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, and material sciences. Although fluorine-nitrogen chemistry has a long and rich history, this field has received increasing interest and made remarkable progress over the past two decades, driven by recent advancements in transition metal and organocatalysis and photochemistry. This review, emphasizing contributions from 2015 to 2023, aims to update the state of the art of the synthesis and applications of nitrogen-based organofluorine functional molecules in organic synthesis and medicinal chemistry. In dedicated sections, we first focus on fluorine-containing reagents organized according to the type of…

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