Neutrophils in Tissue Injury and Repair: Molecular Mechanisms and Therapeutic Targets

Tissue repair represents a highly intricate and ordered dynamic process, critically reliant on the orchestration of immune cells. Among these, neutrophils, the most abundant leukocytes in the body, emerge as the initial immune responders at injury sites. Traditionally recognized for their antimicrobial functions in innate immunity, neutrophils now garner attention for their indispensable roles in tissue repair. This review delves into their novel functions during the early stages of tissue injury. We elucidate the mechanisms underlying neutrophil recruitment and activation following tissue damage and explore their contributions to vascular network formation. Furthermore, we investigate the pivotal role of…

• NN
  National Natural Science Foundation of China

  Award: 82171009
• KR
  Key Research and Development Projects of Shaanxi Province

  Awards: S2024‐YF‐ZDXM‐CY‐0173, 2024SF‐ZDCYL