Tumor-Infiltrating Clonal Hematopoiesis
The Francis Crick Institute · Institut Gustave Roussy · +24 more institutions
Indexed incrossrefpubmed
Abstract
Background
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies can be detected in tumors, a phenomenon we term tumor-infiltrating clonal hematopoiesis (TI-CH). The frequency of TI-CH and its effect on tumor evolution are unclear.
Methods
-mutant CHIP on the biologic features of lung tumors.
Citation impact
72
total citations
- FWCI
- 93.66
- Percentile
- 100%
- References
- 52
Citations per year
Authors
48- OPOriol PichCorresponding
The Francis Crick Institute
- EBElsa Bernard
Institut Gustave Roussy, Protéomique, Réponse Inflammatoire et Spectrométrie de Masse
- MZMaria Zagorulya
The Francis Crick Institute
- ARAndrew Rowan
The Francis Crick Institute
- CPConstandina Pospori
The Francis Crick Institute, Imperial College London
Topics & keywords
Topics
Keywords
- Haematopoiesis
- Cancer research
- Biology
- Genetics
- Stem cell
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.
Funding
- NSNational Science Foundation
- DRDamon Runyon Cancer Research Foundation
- EMEuropean Molecular Biology OrganizationAward: ALTF 831-202
- EHEuropean Hematology AssociationAward: RG112
- EPEdward P. Evans Foundation
- WTWellcome TrustAwards: CC2041, CC2027, CC2085, FC001070, WT209199/Z/17/Z
- FCFrancis Crick Institute
- URUK Research and Innovation
- LULeukaemia UKAward: 2021/JGF/002
- CRCancer Research UKAwards: RCCCDF- Nov21\100005, CC2041, CC2027, CC2085, FC001070, EBSTF-2022/100044
- NINational Institute for Health and Care Research
- RSRoyal SocietyAwards: RSRP\R\210001, RF\ERE\210216
- KKKay Kendall Leukaemia FundAward: KKL1397
- ECEuropean Commission
- ANAgence Nationale de la RechercheAward: ANR-23-IAIHU-0002
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAward: TMAG-3_209224
- UCUniversity College London Hospitals NHS Foundation Trust
- NINational Institutes of Health
- H2Horizon 2020 Framework ProgrammeAward: 101068227
- HEHORIZON EUROPE Framework Programme
- MRMedical Research CouncilAwards: CC2041, CC2027, CC2085, FC001070, MR/N013867/1
- EREuropean Research CouncilAwards: EP/Z534298/1, 835297, 834692
- CFClarendon Fund
- NCNational Cancer InstituteAwards: CA254838-01, CA263816
- HEHORIZON EUROPE European Innovation CouncilAwards: 101068227, 101024529, 890933, 838540