STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation

Despite advancements in interventional coronary reperfusion technologies following myocardial infarction, a notable portion of patients continue to experience elevated mortality rates as a result of myocardial ischemia-reperfusion (MI/R) injury. An in-depth understanding of the mechanisms underlying MI/R injury is crucial for devising strategies to minimize myocardial damage and enhance patient survival. Here, it is discovered that during MI/R, double-stranded DNA (dsDNA)-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signal accumulates, accompanied by high rates of myocardial ferroptosis. The specific deletion of cgas or Sting in cardiomyocytes, resulting in the inhibition of oxidative…

• NN
  National Natural Science Foundation of China

  Awards: 82241203, 82270487, 82200507, 82200502
• CA
  Chinese Academy of Medical Sciences
• NS
  Natural Science Foundation of Shandong Province

  Awards: ZR2023JQ030, 2021ZDSYS05, ZR2024ZD09
• NK
  National Key Research and Development Program of China

  Award: 2021YFF0501403
• P2
  Project 211

  Award: BP0719033
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2023QNTD003