reviewMolecular NeurodegenerationApr 24, 2025GOLD OA

Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities

AAAbdel Ali BelaidiAIAshley I. BushSAScott Ayton

Florey Institute of Neuroscience and Mental Health

PubMed
Indexed incrossrefdoajpubmed

Abstract

Apolipoprotein E (APOE- gene; apoE- protein) is the strongest genetic modulator of late-onset Alzheimer's disease (AD), with its three major isoforms conferring risk for disease ε2

Citation impact

58
total citations
FWCI
54.21
Percentile
100%
References
249
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • Apolipoprotein E
  • Neuroinflammation
  • Neuroscience
  • Disease
  • Neuropathology
  • Autophagy
  • Alzheimer's disease
  • Medicine
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