articleNucleic Acids ResearchApr 25, 2025GOLD OA

antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation

KBKai BlinSJSimon J. ShawLVLisa VaderJSJudit SzeneiZLZachary L. Reitz

Novo Nordisk Foundation · Technical University of Denmark · +13 more institutions

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Abstract

Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceuticals or agrochemicals. Over the past decades, advancements in genome sequencing have enabled the identification of large numbers of biosynthetic gene clusters directly from microbial genomes. Since its inception in 2011, antiSMASH (https://antismash.secondarymetabolites.org/), has become the leading tool for detecting and characterizing these gene clusters in bacteria and fungi. This paper introduces version 8 of antiSMASH, which has increased the number of detectable…

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Topics & keywords

Topics
Keywords
  • Nonribosomal peptide
  • Biology
  • Gene cluster
  • Genome
  • Computational biology
  • Gene
  • Natural product
  • Polyketide
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