Synergizing Catalysis with Post-catalysis Pseudo-Iron Release by Building Dynamic Catalytic Active Sites in Diatomic Nanozymes for Boosting Cancer Therapy

Biomimetic nanozymes hold considerable promise for cancer therapy, but their therapeutic potential is often constrained by their limited catalytic activity. Here, we present a Ga/Zn diatomic nanozyme (Ga/Zn-NC) with a well-defined geometric structure and electronic configuration designed to emulate peroxidase and glutathione oxidase with exceptional catalytic activities, enabling cascade catalysis. We demonstrate that the formation of Ga-Zn metal bonding is essential for accelerating electron transfer and reducing the reaction energy barrier, thus enhancing the catalytic performance. Within the tumor microenvironment, the catalytic actions of Ga/Zn-NC induce oxidative damage and sensitize breast cancer cells…

• NN
  National Natural Science Foundation of China

  Awards: 81471784, 82072065, 52303221
• FR
  Fundamental Research Funds for the Central Universities

  Awards: E2EG6802X2, E2E46801