Mannosylated MOF Encapsulated in  Lactobacillus  Biofilm for Dual‐Targeting Intervention Against Mammalian  Escherichia coli  Infections

Ma, Ning; Cai, Kun; Zhao, Jingwen; Liu, Chunchen; Li, Huahui; Tan, Peng; Li, Yuan; Li, Defa; Ma, Xi

doi:10.1002/adma.202503056

articleAdvanced MaterialsApr 25, 2025BRONZE OA

Mannosylated MOF Encapsulated in Lactobacillus Biofilm for Dual‐Targeting Intervention Against Mammalian Escherichia coli Infections

NMNing Ma KCKun Cai JZJingwen Zhao CLChunchen Liu HLHuahui Li

China Agricultural University · Tianjin Medical University General Hospital · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Pathogenic bacterial infections pose a major concern, especially concerning mammalian enteritis and diarrhea. Compared to conventional antibiotic intervention, metal-organic frameworks (MOFs) exhibit superior antibacterial properties and lower cytotoxicity, demonstrating great promise in the treatment of pathogen-induced diarrhea. However, the achievement of their precise targeted delivery is still a significant challenge. Herein, a novel precision nano-system with a dual-targeting approach for treating intestinal infections caused by Escherichia coli (E. coli) is designed. First, Zn-MOF was synthesized based on ZnO, which possessed enhanced elimination of planktonic bacteria and biofilms. Through…

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46

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FWCI: 19.19
Percentile: 100%
References: 49

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Topics & keywords

Topics

Keywords

Escherichia coli
Biofilm
Microbiology
Probiotic
Biology
Antibiotics
Antimicrobial
Pilus

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