Recent Progress of Molecular Design in Organic Type I Photosensitizers

Photodynamic therapy (PDT) represents a high-efficient and non-invasive therapeutic modality for current and future tumor treatments, drawing extensive attention in the fields of antitumor drug and clinical phototherapy. In recent years, the photosensitizer (PS) market and PDT clinical applications have expanded to address various cancers and skin diseases. However, hypoxic environment within tumors poses a substantial challenge to the therapeutic capability of reactive oxygen species-dependent PDT. Consequently, researches have increasingly focus from the type II to type I PDT mechanism, which relies on radical production with less or no oxygen dependence. Despite significant progress in the development of…

• NN
  National Natural Science Foundation of China

  Awards: 22338005, 21925802, 22090011
• CP
  China Postdoctoral Science Foundation

  Award: 2024M752119
• FR
  Fundamental Research Funds for the Central Universities

  Awards: DUT22LAB608, DUT22LAB601
• BA
  Basic and Applied Basic Research Foundation of Guangdong Province

  Award: 2023B1515120001