reviewPEDIATRICSApr 28, 2025HYBRID OA

Patent Ductus Arteriosus in Preterm Infants

NANamasivayam AmbalavananSWSusan W. AucottASArash SalavitabarVYVictor Y. LevyEEEric Eichenwald

University of Alabama at Birmingham · Greater Baltimore Medical Center · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Despite extensive research in basic science and in clinical settings with thousands of infants over decades, uncertainty and controversy persist regarding the significance, assessment, and management of the patent ductus arteriosus (PDA) in preterm infants, resulting in substantial variability in clinical approach. This clinical report aims to succinctly review the available evidence to guide evaluation and treatment of preterm infants with prolonged ductal patency. Delayed closure of the PDA is common in preterm infants, particularly at more extreme immaturity. Echocardiography is essential for confirming the presence of a PDA and assessing hemodynamic significance. Medical closure of a PDA using ibuprofen or…

Citation impact

44
total citations
FWCI
48.57
Percentile
100%
References
107
Citations per year

Authors

26

Topics & keywords

Keywords
  • Medicine
  • Ductus arteriosus
  • Closure (psychology)
  • Cardiac catheterization
  • Ibuprofen
  • Clinical significance
  • Intensive care medicine
  • Clinical trial
UN Sustainable Development Goals
  • Good health and well-being
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