Human papilloma virus (HPV) mediated cancers: an insightful update

Human papillomavirus (HPV), a DNA virus, is a well-documented causative agent of several cancers, including cervical, vulvar, vaginal, penile, anal, and head & neck cancers. Major factors contributing to HPV-related cancers include persistent infection and the oncogenic potential of particular HPV genotypes. High-risk HPV strains, particularly HPV-16 and HPV-18, are responsible for over 70% of cervical cancer cases worldwide, as well as a significant proportion of other genital and head and neck cancers. At the molecular level, the oncogenic activity of these viruses is driven by the overexpression of E6 and E7 oncoproteins. These oncoproteins dysregulate the cell cycle, inhibit apoptosis, and promote the…

• UA
  United Arab Emirates University
• CI
  Canadian Institutes of Health Research

  Award: PJT-173491
• CO
  College of Medicine and Health Sciences, United Arab Emirates University

  Award: UPAR fund G00004634
• CO
  College of Graduate Studies, United Arab Emirates University

  Award: start up: G0000429