articleThe Lancet OncologyApr 29, 2025Closed access

Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial

ELEmil LouMSModassir S ChoudhryTKTimothy K. StarrTDTimothy D. FolsomJBJason Bell

University of Minnesota · University of Minnesota Medical Center · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

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46
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FWCI
36.83
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100%
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23
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Authors

33

Topics & keywords

Topics
Keywords
  • CRISPR
  • Colorectal cancer
  • Medicine
  • CISH
  • Immune checkpoint
  • Cancer research
  • Immune system
  • Cancer
UN Sustainable Development Goals
  • Good health and well-being
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