articleJournal of the American Chemical SocietyApr 30, 2025Closed access

Self-Adaptive Release of Stem Cell-Derived Exosomes from a Multifunctional Hydrogel for Accelerating MRSA-Infected Diabetic Wound Repair

XWXiang WangJDJiantong DongJKJingjing KangXCXujing ChenXHXiaoqin Hong

Nankai University · Anhui Medical University · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Chronic diabetic wounds are prone to severe skin necrosis and bacterial infections, with elevated reactive oxygen species (ROS) and persistent inflammation further hindering the healing process. Developing smart dressings with multifunctional therapeutic capabilities to simultaneously combat infections, reduce oxidative stress, alleviate inflammation, and promote tissue regeneration remains a significant challenge. Here, we introduce a self-adaptive yet multifunctional hydrogel (Exo-Gel) designed to accelerate methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wound repair. Exo-Gel utilizes choline phosphate (CP) groups to both anchor stem cell-derived exosomes (Exo) via electrostatic…

Citation impact

55
total citations
FWCI
42.61
Percentile
100%
References
66
Citations per year

Authors

9

Topics & keywords

Topics
Keywords
  • Wound healing
  • Microvesicles
  • Chemistry
  • Inflammation
  • Oxidative stress
  • Reactive oxygen species
  • Regeneration (biology)
  • Angiogenesis
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