Dissolving microneedles in transdermal drug delivery: A critical analysis of limitations and translation challenges

Microneedles (MNs) have emerged as an innovative approach for transdermal drug delivery, offering an efficient and minimally invasive alternative to conventional injections and oral delivery systems. While their potential has been widely recognized and extensively studied, the translation of MN technology into clinical practice remains limited. Despite the vast amount of published research, much of it involves over-complexification without addressing the core barriers to practical application. For example, dissolving/degradable MNs face key limitations such as poor drug loading capacity, low dosing consistency, and challenges in delivering effective therapeutic concentrations. These constraints restrict their…

• UL
  Université Laval
• UD
  Université de Montréal
• CI
  Canadian Institutes of Health Research

  Award: PJT.165822
• NS
  Natural Sciences and Engineering Research Council of Canada

  Award: RGPIN-2018-05076
• FD
  Fonds de Recherche du Québec - Santé
• FD
  Fonds de recherche du Québec – Nature et technologies

  Award: 331629
• AC
  Association canadienne du médicament générique
• FD
  Faculté de pharmacie, Université de Montréal