Rabies Virus Targeting NIR-II Phototheranostics

Rabies is a viral disease with an almost 100% fatality rate, primarily transmitted through bites from infected animals, with a long incubation period and no effective clinical treatments to date. Herein, we developed the first fluorescent nanotheranostic probe in the second near-infrared (NIR) window capable of efficiently crossing the blood–brain barrier (BBB), precisely targeting rabies virus (RABV), and enabling safe photodynamic therapy (PDT). This probe is based on a novel NIR-II organic polyacetylene fluorophore, DK, which self-assembles via a click reaction with a nanoparticle carrier, N3-PEG2000-R, that we synthesized with a high biocompatibility and BBB permeability. The probe surface is further…

• NR
  National Research Foundation of Korea
• CS
  China Scholarship Council

  Award: 202106270027
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2662023PY005
• HE
  H2020 European Research Council

  Award: 771443