Exploring tumor-associated macrophages in glioblastoma: from diversity to therapy

Glioblastoma is the most aggressive and lethal cancer of the central nervous system, presenting substantial treatment challenges. The current standard treatment, which includes surgical resection followed by temozolomide and radiation, offers limited success. While immunotherapies, such as immune checkpoint inhibitors, have proven effective in other cancers, they have not demonstrated significant efficacy in GBM. Emerging research highlights the pivotal role of tumor-associated macrophages (TAMs) in supporting tumor growth, fostering treatment resistance, and shaping an immunosuppressive microenvironment. Preclinical studies show promising results for therapies targeting TAMs, suggesting potential in…

• NS
  Natural Science Foundation of Shandong Province

  Awards: No.ZR2024QH042, NO.ZR2023MH202, No. ZR2022MH174
• FF
  Foundation for Innovative Research Groups of the National Natural Science Foundation of China

  Awards: No.82303083, No. 82203472