reviewSignal Transduction and Targeted TherapyMay 4, 2025GOLD OA

Meningeal lymphatic drainage: novel insights into central nervous system disease

QZQiang ZhangYNYin NiuYLYingpei LiCXChenyang XiaZCZhi Chen

Army Medical University · Southwest Hospital · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage dysfunction include neurodegenerative diseases, stroke, infections, traumatic brain injury, tumors, functional cranial disorders, and hydrocephalus. However, the understanding of the regulatory and damage mechanisms of meningeal lymphatics under physiological and pathological conditions is currently limited. Given the importance of a profound understanding of the interplay between meningeal lymphatic drainage and CNS diseases, this review covers seven key…

Citation impact

46
total citations
FWCI
32.93
Percentile
100%
References
518
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • Lymphatic system
  • Meninges
  • Pathology
  • Medicine
  • Central nervous system
  • Glymphatic system
  • Neuroscience
  • Cerebrospinal fluid
UN Sustainable Development Goals
  • Good health and well-being
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