Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut
Chinese Academy of Sciences · National Center for Nanoscience and Technology · +5 more institutions
Abstract
Biodegradable polylactic acid (PLA) plastics have been praised as an effective solution to the global pollution caused by petroleum-based plastics, and their widespread use in food packaging and disposable tableware has resulted in increased oral exposure to PLA microplastics (PLA-MPs). Despite their eco-friendly and biodegradable reputation, the in vivo behaviors of PLA-MPs concerning fermentation, carbon cycle, and adverse effects remain unknown. Here, we showed that gut microbiota from the colon can effectively degrade the PLA-MPs by secreting esterase FrsA, whereas esterase FrsA-producing bacteria were identified to dominate this behavior in male C57BL/6 mice. Using isotope tracing and multiomics…
Citation impact
- FWCI
- 17.30
- Percentile
- 100%
- References
- 69
Authors
10- LBLin Bao
Chinese Academy of Sciences, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- XCXuejing CuiCorresponding
Academy of Medical Sciences, Chinese Academy of Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- TZTao Zeng
Sun Yat-sen University
- GLGuanyu Liu
Chinese Academy of Sciences, National Center for Nanoscience and Technology, University of Chinese Academy of Sciences
- WLWenjia Lai
National Center for Nanoscience and Technology
Topics & keywords
- Polylactic acid
- Microplastics
- Gut flora
- Tricarboxylic acid
- Chemistry
- Citric acid cycle
- Metabolism
- Biochemistry
- Responsible consumption and production