Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease

Caspases are critical regulators of cell death, development, innate immunity, host defense, and disease. Upon detection of pathogens, damage-associated molecular patterns, cytokines, or other homeostatic disruptions, innate immune sensors, such as NLRs, activate caspases to initiate distinct regulated cell death pathways, including non-lytic (apoptosis) and innate immune lytic (pyroptosis and PANoptosis) pathways. These cell death pathways are driven by specific caspases and distinguished by their unique molecular mechanisms, supramolecular complexes, and enzymatic properties. Traditionally, caspases are classified as either apoptotic (caspase-2, -3, -6, -7, -8, -9, and -10) or inflammatory (caspase-1, -4, -5,…

• AL
  American Lebanese Syrian Associated Charities

  Awards: AI124346, AR056296, AI101935
• NI
  National Institutes of Health

  Awards: AR056296, CA253095, AI101935, AI124346, AI160179
• NC
  National Cancer Institute

  Award: CA253095
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: AI124346, AI101935, AI160179
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Award: AR056296