Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

Neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, Huntington's disease, and Amyotrophic Lateral Sclerosis) are major health threats for the aging population and their prevalences continue to rise with the increasing of life expectancy. Although progress has been made, there is still a lack of effective cures to date, and an in-depth understanding of the molecular and cellular mechanisms of these neurodegenerative diseases is imperative for drug development. Protein phosphorylation, regulated by protein kinases and protein phosphatases, participates in most cellular events, whereas aberrant phosphorylation manifests as a main cause of diseases. As evidenced by pharmacological and pathological studies,…

• NN
  National Natural Science Foundation of China

  Awards: 32070961, 2023ZD0507200
• SU
  Sichuan University
• NS
  National Science and Technology Major Project

  Award: 2023ZD0507200
• NS
  Natural Science Foundation of Sichuan Province
• WC
  West China Hospital, Sichuan University