Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms
Université Larbi Tébessi · University of Béjaïa · +2 more institutions
Abstract
Staphylococcus aureus is a formidable human pathogen responsible for infections ranging from superficial skin lesions to life-threatening systemic diseases. This review synthesizes current knowledge on its pathogenesis, emphasizing colonization dynamics, virulence mechanisms, biofilm formation, and antibiotic resistance. By analyzing studies from PubMed, Scopus, and Web of Science, we highlight the pathogen’s adaptability, driven by surface adhesins (e.g., ClfB, SasG), secreted toxins (e.g., PVL, TSST-1), and metabolic flexibility in iron acquisition and amino acid utilization. Nasal, skin, and oropharyngeal colonization are reservoirs for invasive infections, with biofilm persistence and horizontal gene…
Citation impact
- FWCI
- 117.46
- Percentile
- 100%
- References
- 311
Authors
6Topics & keywords
- Virulence
- Microbiology
- Antibiotic resistance
- Bacterial adhesin
- Staphylococcus aureus
- Pathogen
- Human pathogen
- Biology