articleNucleic Acids ResearchMay 7, 2025GOLD OA

The UniProt website API: facilitating programmatic access to protein knowledge

European Bioinformatics Institute

PubMed
Indexed incrossrefdoajpubmed

Abstract

The UniProt REST API is a freely available, open-access resource that powers the UniProt.org website and gives users flexible programmatic interaction with protein knowledge data. It provides access to UniProtKB, UniRef, UniParc, Proteomes, GeneCentric, ARBA, UniRule, and the ID Mapping tool, along with supporting data and controlled vocabularies. Users can access the API with their favorite programming language and generate example code snippets to access the UniProt databases using the API documentation page (https://www.uniprot.org/api-documentation) in various languages. API results can be returned and downloaded in various formats. With an average of 303 million requests per month over the last year, the…

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