Breakthroughs and challenges of organoid models for assessing cancer immunotherapy: a cutting-edge tool for advancing personalised treatments
Jiangsu Cancer Hospital · Second Affiliated Hospital of Nanjing Medical University · +2 more institutions
Abstract
Organoid models are powerful tools for evaluating cancer immunotherapy that provide a more accurate representation of the tumour microenvironment (TME) and immune responses than traditional models. This review focuses on the latest advancements in organoid technologies, including immune cell co-culture, 3D bioprinting, and microfluidic systems, which enhance the modelling of TME and facilitate the assessment of immune therapies such as immune checkpoint inhibitors (ICIs), CAR-T therapies, and oncolytic viruses. Although these models have great potential in personalised cancer treatment, challenges persist in immune cell diversity, long-term culture stability, and reproducibility. Future developments…
Citation impact
- FWCI
- 40.51
- Percentile
- 100%
- References
- 155
Authors
4- QWQian WangCorresponding
Jiangsu Cancer Hospital, Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University
- FYFangwei Yuan
Huaian First People’s Hospital
- XZXianglin Zuo
Jiangsu Cancer Hospital
- MLMing Li
Jiangsu Cancer Hospital, Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University
Topics & keywords
- Organoid
- Immunotherapy
- Tumor microenvironment
- Cancer immunotherapy
- Oncolytic virus
- Immune system
- Cancer
- Immune checkpoint