Targeting vascular endothelial growth receptor-2 (VEGFR-2): structural biology, functional insights, and therapeutic resistance
Chosun University · Kyung Hee University
Abstract
Angiogenesis, the process of new blood vessel formation, is a fundamental physiological process implicated in several pathological disorders. The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for angiogenesis and vasculogenesis. Among them, the tyrosine kinase receptor VEGFR-2 is primarily expressed in endothelial cells (ECs). These cells regulate various physiological responses, including differentiation, cell proliferation, migration, and survival, by binding to VEGF mitogens. Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) is a key regulator of this process, making it a prime target for therapeutic intervention. Several drugs targeting VEGFR-2 have been…
Citation impact
- FWCI
- 34.94
- Percentile
- 100%
- References
- 156
Authors
7Topics & keywords
- Angiogenesis
- Vasculogenesis
- Cell biology
- Cancer research
- Vascular endothelial growth factor
- Kinase insert domain receptor
- Regulator
- Receptor tyrosine kinase
- Good health and well-being