The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer
Central South University · Xiangya Hospital Central South University · +5 more institutions
Abstract
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form of cell death that is crucial for tumor suppression and therapeutic resistance. As a result, manipulating copper levels has garnered increasing interest as an innovative approach to cancer therapy. In this review, we first delineate copper homeostasis at both cellular and systemic levels, clarifying copper's protumorigenic and antitumorigenic functions in cancer. We then outline the key milestones and molecular mechanisms of cuproptosis, including both…
Citation impact
- FWCI
- 87.71
- Percentile
- 100%
- References
- 547
Authors
10- ZGZiyu GuoCorresponding
Central South University, Xiangya Hospital Central South University
- DCDanyao Chen
Central South University, Xiangya Hospital Central South University
- LYLei Yao
Central South University, Xiangya Hospital Central South University
- YSYuming Sun
Central South University, Xiangya Hospital Central South University
- DLDaishi Li
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Cancer
- Cancer cell
- Cancer therapy
- Mechanism (biology)
- Biology
- Cancer treatment
- Metastasis
- Computational biology
- Zero hunger