Trends in Cancer Incidence and Mortality Rates in Early-Onset and Older-Onset Age Groups in the United States, 2010–2019

We estimated age-standardized cancer incidence (2010-2019) and mortality rates (2010-2022) in the United States to investigate whether cancer rates have increased at younger ages. Fourteen cancers had incidence rates that increased in at least one early-onset age group (i.e., 15-29-, 30-39-, and 40-49-year-olds)-9 of these also increased in at least one older-onset age group (i.e., 50-59, 60-69, and 70-79; i.e., female breast, colorectal, kidney, testicular, uterine and pancreatic cancers, and several lymphoid neoplasms). The largest absolute increases in 2019 compared with expected diagnoses based on 2010 rates were female breast (n = 4,834 additional cancers), colorectal (n = 2,099), kidney (n = 1,793), and…

• IO
  Institute of Cancer Research
• NC
  National Cancer Institute