Structural characterization of a pectic polysaccharide from Rubus chingii Hu. unripe fruits and its efficacy in inhibiting intestinal lipid absorption in vivo

Excessive lipid intake is a major contributor to obesity, and inhibiting intestinal lipid absorption is considered an effective strategy to mitigate this condition. In this study, a pectic polysaccharide designated as RCP-2-3 was obtained from Rubus chingii Hu. unripe fruits and its potential inhibitory effect on intestinal lipid absorption in vivo was investigated. Structural studies revealed that RCP-2-3 (8.54 kDa) is a homogeneous pectic polysaccharide composed of homogalacturonan (HG) and rhamnogalacturonan II (RG-II) domains in a 4.4:4.1 mass ratio. Treatment with RCP-2-3 for 7 days effectively reduced postprandial serum triglyceride (TG) accumulation and lipid absorption in BODIPY-labeled soybean oil-fed…

• NN
  National Natural Science Foundation of China

  Award: 82474066
• ZC
  Zhejiang Chinese Medical University

  Award: 2023JKZKTS20
• NS
  Natural Science Foundation of Zhejiang Province

  Award: ZCLY24H2801