The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity

BACKGROUND: Bile acids, derived from cholesterol in the liver, consist a steroidal core. Primary bile acids and secondary bile acids metabolized by the gut microbiota make up the bile acid pool, which modulate nuclear hormone receptors to regulate immunity. Disruptions in the crosstalk between bile acids and the gut flora are intimately associated with the development and course of gastrointestinal inflammation. AIM OF REVIEW: This review provides an extensive summary of bile acid production, transport and metabolism. It also delves into the impact of bile acid metabolism on the body and explores the involvement of bile acid-microbiota interactions in various disease states. Furthermore, the potential of…

• NN
  National Natural Science Foundation of China

  Award: 32372889
• NK
  National Key Research and Development Program of China

  Award: 2023YFD1301101
• FR
  Fundamental Research Funds for the Central Universities

  Award: 226-2024-00080