reviewToxicology ReportsMay 10, 2025GOLD OA

Micro- and nanoplastic toxicity in humans: Exposure pathways, cellular effects, and mitigation strategies

FJFaezeh JahediNJNeamatollah Jaafarzadeh Haghighi Fard

Ahvaz Jundishapur University of Medical Sciences

PubMed
Indexed incrossrefdoajpubmed

Abstract

Microplastics and nanoplastics (MNPs) are emerging environmental contaminants with increasing scientific evidence suggesting their potential risks to human health. The present review systematically explores the pathways through which these particles enter the human body, the cellular and molecular mechanisms of their toxicity, and current strategies to mitigate their effects. A structured literature review was conducted following PRISMA guidelines, focusing on studies published between 2019 and 2024 across major scientific databases. MNPs primarily enter the human system via ingestion, inhalation, and dermal exposure. Once internalized, they can accumulate in various organs and trigger oxidative stress,…

Citation impact

52
total citations
FWCI
20.65
Percentile
100%
References
140
Citations per year

Authors

2

Topics & keywords

Keywords
  • Toxicity
  • Chemical toxicity
  • Computational biology
  • Biochemical engineering
  • Chemistry
  • Computer science
  • Biology
  • Engineering
UN Sustainable Development Goals
  • Climate action
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