Engineered Nanozymes with Asymmetric Mn─O─Ce Sites for Intratumorally Leveraged Multimode Therapy
Northeast Forestry University · Zhejiang Sci-Tech University · +1 more institution
Abstract
Abstract Due to the enhanced flexibility of catalytic sites and synergistic effects between dual‐atom active centers, dual‐atom nanozymes stand out in the tumor catalytic therapy. However, precisely regulating the d‐band centers of diatomic sites to break the linear‐scaling relationship between intermediates remains a challenge. Herein, the hydrothermally mass‐produced oxygen vacancies‐engineered bimetallic silicate bio‐nanoplatform with highly asymmetric O‐bridged cerium─manganese (Ce─Mn) diatomic catalytic centers (CeMn‐V DAs/EGCG@HA) is meticulously constructed by loading epigallocatechin‐3‐gallate (EGCG) and modifying with hyaluronic acid (HA) for multimodal synergistic cancer therapy. Theoretical…
Citation impact
- FWCI
- 26.37
- Percentile
- 100%
- References
- 117
Authors
10Topics & keywords
- Materials science
- Nanotechnology