Platelets and diseases: signal transduction and advances in targeted therapy
Shanghai Jiao Tong University · Shanghai Sixth People's Hospital · +1 more institution
Abstract
Platelets are essential anucleate blood cells that play pivotal roles in hemostasis, tissue repair, and immune modulation. Originating from megakaryocytes in the bone marrow, platelets are small in size but possess a highly specialized structure that enables them to execute a wide range of physiological functions. The platelet cytoplasm is enriched with functional proteins, organelles, and granules that facilitate their activation and participation in tissue repair processes. Platelet membranes are densely populated with a variety of receptors, which, upon activation, initiate complex intracellular signaling cascades. These signaling pathways govern platelet activation, aggregation, and the release of…
Citation impact
- FWCI
- 70.25
- Percentile
- 100%
- References
- 545
Authors
7- YTYuchen TianCorresponding
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- ZYZong Yao
The University of Western Australia
- YPYidan Pang
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- ZZZhikai Zheng
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
- YMYiyang Ma
Shanghai Jiao Tong University, Shanghai Sixth People's Hospital
Topics & keywords
- Platelet
- Platelet activation
- Signal transduction
- Hemostasis
- Immune system
- Medicine
- Inflammation
- Cell biology
- Good health and well-being