articleWorld PsychiatryMay 15, 2025BRONZE OA

The efficacy, mechanisms and implementation of physical activity as an adjunctive treatment in mental disorders: a meta‐review of outcomes, neurobiology and key determinants

VIB-KU Leuven Center for Brain & Disease Research · KU Leuven · +16 more institutions

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Abstract

Research examining physical activity interventions for mental disorders has grown exponentially in the past decade. At this critical juncture, there is a need to synthesize the best evidence to guide researchers, clinicians and people with lived experience. This meta-review aimed to systematically identify and comprehensively evaluate the current evidence about: a) the efficacy of physical activity interventions on mental, cognitive and physical outcomes for individuals with mental disorders; b) the potential neurobiological, psychosocial and behavioral mechanisms underlying the observed effects; and c) the barriers and facilitators for individuals to successfully engage in these interventions. Our systematic…

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