Dynamic single-cell metabolomics reveals cell-cell interaction between tumor cells and macrophages
Peking University · Beijing National Laboratory for Molecular Sciences
Abstract
Single-cell metabolomics reveals cell heterogeneity and elucidates intracellular molecular mechanisms. However, general concentration measurement of metabolites can only provide a static delineation of metabolomics, lacking the metabolic activity information of biological pathways. Herein, we develop a universal system for dynamic metabolomics by stable isotope tracing at the single-cell level. This system comprises a high-throughput single-cell data acquisition platform and an untargeted isotope tracing data processing platform, providing an integrated workflow for dynamic metabolomics of single cells. This system enables the global activity profiling and flow analysis of interlaced metabolic networks at the…
Citation impact
- FWCI
- 26.33
- Percentile
- 100%
- References
- 63
Authors
6- YVY. Victoria ZhangCorresponding
Peking University, Beijing National Laboratory for Molecular Sciences
- MSMingying Shi
Peking University, Beijing National Laboratory for Molecular Sciences
- MLMingxuan Li
Peking University, Beijing National Laboratory for Molecular Sciences
- SQShaojie Qin
Peking University, Beijing National Laboratory for Molecular Sciences
- DMDaiyu Miao
Peking University, Beijing National Laboratory for Molecular Sciences
Topics & keywords
- Metabolomics
- Cell
- Cell biology
- Computational biology
- Chemistry
- Biology
- Bioinformatics
- Biochemistry
- Zero hunger