Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives
Hongik University · Sookmyung Women's University · +3 more institutions
Abstract
Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maintenance of homeostasis. VEGF ligands and their receptors orchestrate endothelial cell proliferation, migration, and survival, playing a pivotal role in dynamic vascular remodeling. Dysregulated VEGF signaling drives diverse pathological conditions, including tumor angiogenesis, cardiovascular diseases, and ocular disorders. Excessive VEGF activity promotes tumor growth, invasion, and metastasis, while insufficient signaling contributes to impaired wound healing and ischemic…
Citation impact
- FWCI
- 128.25
- Percentile
- 100%
- References
- 760
Authors
6Topics & keywords
- Angiogenesis
- Lymphangiogenesis
- Vasculogenesis
- Vascular endothelial growth factor
- Medicine
- Metastasis
- Cancer research
- Receptor tyrosine kinase
- Good health and well-being