Targeting oxidative stress-mediated regulated cell death as a vulnerability in cancer
Central South University · Xiangya Hospital Central South University · +2 more institutions
Abstract
Reactive oxygen species (ROS), regulators of cellular behaviors ranging from signaling to cell death, have complex production and control mechanisms to maintain a dynamic redox balance under physiological conditions. Redox imbalance is frequently observed in tumor cells, where ROS within tolerable limits promote oncogenic transformation, while excessive ROS induce a range of regulated cell death (RCD). As such, targeting ROS-mediated regulated cell death as a vulnerability in cancer. However, the precise regulatory networks governing ROS-mediated cancer cell death and their therapeutic applications remain inadequately characterized. In this Review, we first provide a comprehensive overview of the mechanisms…
Citation impact
- FWCI
- 27.46
- Percentile
- 100%
- References
- 554
Authors
11- DCDanyao ChenCorresponding
Central South University, Xiangya Hospital Central South University
- ZGZiyu Guo
Central South University, Xiangya Hospital Central South University
- LYLei Yao
Central South University, Xiangya Hospital Central South University
- YSYuming Sun
Central South University, Xiangya Hospital Central South University
- YDYating Dian
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Oxidative stress
- Reactive oxygen species
- Programmed cell death
- Cancer cell
- Cell biology
- Mitochondrial ROS
- Biology
- Context (archaeology)