Nose-to-brain drug delivery: from bench to bedside
University of Veterinary Medicine Hannover, Foundation · Hannover Re (Germany)
Abstract
There is increasing interest in nose-to-brain delivery as an innovative drug delivery strategy for neurodegenerative disorders such as Parkinson's or Alzheimer's disease. The unique anatomy of the nose-brain interface facilitates direct drug transport via the olfactory and trigeminal pathways to the brain, bypassing the blood-brain barrier. Different administration techniques as well as advanced drug formulations like targeted nanoparticles and thermoresponsive systems have been explored to improve the delivery efficiency and the therapeutic efficacy. This review provides an up-to-date perspective on this fast-developing field, and discusses different studies on safety and pharmacokinetic properties. A…
Citation impact
- FWCI
- 40.93
- Percentile
- 100%
- References
- 274
Authors
3Topics & keywords
- Medicine
- Drug delivery
- Nasal administration
- Bench to bedside
- Drug delivery to the brain
- Neuroscience
- Migraine
- Blood–brain barrier