Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation

Abstract The involvement of gut microbiota in calcific aortic valve disease (CAVD) pathogenesis remains underexplored. Here, we provide evidence for a strong association between the gut microbiota and CAVD development. ApoE −/− mice were stratified into easy‐ and difficult‐ to calcify groups using neural network and cluster analyses, and subsequent faecal transplantation and dirty cage sharing experiments demonstrated that the microbiota from difficult‐to‐calcify mice significantly ameliorated CAVD. 16S rRNA sequencing revealed that reduced abundance of Faecalibacterium prausnitzii ( F. prausnitzii ) was significantly associated with increased calcification severity. Association analysis identified F.…

• NN
  National Natural Science Foundation of China

  Awards: 82370379, 82300416, 82200410, 2021YFA1101900, 82204659, 81930052
• CP
  China Postdoctoral Science Foundation

  Award: 2024M750855
• HU
  Hubei University