reviewChemical Society ReviewsJan 1, 2025Closed access

Suzuki–Miyaura (hetero-)aryl cross-coupling: recent findings and recommendations

JWJonas W. MeringdalDMDirk Menche

University of Bonn

PubMed
Indexed incrossrefpubmed

Abstract

The Suzuki-Miyaura cross-coupling is a powerful method for carbon-carbon bond formation, widely applied with various substrates, catalysts, reagents and solvents. However, numerous reported protocols make finding optimal conditions for a specific substrate time-consuming. This tutorial review provides a comprehensive overview on recent developments in Suzuki-Miyaura reactions, focusing on optimizing the most common application: palladium and nickel phosphine catalyzed (hetero-)aryl bond formation. Key mechanistic insights into ligand selection, base and boron reagent choice as well as potential additives, and their effects on the reaction outcome are discussed in detail. Based on a systematic analysis, these…

Citation impact

49
total citations
FWCI
35.76
Percentile
100%
References
63
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Aryl
  • Reagent
  • Palladium
  • Combinatorial chemistry
  • Ligand (biochemistry)
  • Selection (genetic algorithm)
  • Chemistry
  • Base (topology)
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