Extracellular matrix: unlocking new avenues in cancer treatment
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Abstract
The extracellular matrix (ECM) plays a critical role in cancer progression by influencing tumor growth, invasion, and metastasis. This review explores the emerging therapeutic strategies that target the ECM as a novel approach in cancer treatment. By disrupting the structural and biochemical interactions within the tumor microenvironment, ECM-targeted therapies aim to inhibit cancer progression and overcome therapeutic resistance. We examine the current state of ECM research, focusing on key components such as collagen, laminin, fibronectin, periostin, and hyaluronic acid, and their roles in tumor biology. Additionally, we discuss the challenges associated with ECM-targeted therapies, including drug delivery,…
Citation impact
46
total citations
- FWCI
- 55.39
- Percentile
- 100%
- References
- 278
Citations per year
Authors
3Topics & keywords
Topics
Keywords
- Extracellular matrix
- Fibronectin
- Hyaluronic acid
- Medicine
- Tumor microenvironment
- Metastasis
- Laminin
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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