Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond
Tongji University · Chinese Academy of Sciences · +5 more institutions
Abstract
Cuproptosis, a novel form of copper (Cu)-dependent programmed cell death, is induced by directly binding Cu species to lipoylated components of the tricarboxylic acid (TCA) cycle. Since its discovery in 2022, cuproptosis has been closely linked to the field of materials science, offering a biological basis and bright prospects for the use of Cu-based nanomaterials in various disease treatments. Owing to the unique physicochemical properties of nanomaterials, Cu delivery nanosystems can specifically increase Cu levels at disease sites, inducing cuproptosis to achieve disease treatment while minimizing the undesirable release of Cu in normal tissues. This innovative nanomaterial-mediated cuproptosis, termed as…
Citation impact
- FWCI
- 26.60
- Percentile
- 100%
- References
- 498
Authors
15- LMLijie Mao
Tongji University, Chinese Academy of Sciences, Shanghai Tenth People's Hospital, Shanghai Institute of Ceramics
- JLJi Lu
Tongji University, Shanghai Tenth People's Hospital
- XWXinyu Wen
Tongji University, Shanghai Skin Disease Hospital
- ZSZhiyi Song
Tongji University, Shanghai Tenth People's Hospital
- CSCai Sun
Tongji University, Shanghai Tenth People's Hospital
Topics & keywords
- Nanotechnology
- Rational design
- Medicine
- Computer science
- Materials science
Funding
- SKShanghai Key Basic Research ProgramAwards: 21JC1406000, 23DX1900200
- SMShanghai Municipal Health CommissionAward: 20224Y0010
- NNNational Natural Science Foundation of ChinaAwards: 52202352, 22335006
- SAScience and Technology Commission of Shanghai MunicipalityAward: 23DX1900201
- NKNational Key Research and Development Program of ChinaAward: 2022YFB3804500
- FRFundamental Research Funds for the Central UniversitiesAwards: 22120220618, 22120230237, 2023-3-YB-11