Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia

The treatment of diabetic abscess remains highly challenging due to the complex wound healing environment, which includes bacterial infection, hypoxia, and pain, severely compromising patients' quality of life. Developing effective treatment strategies to address these multifaceted issues continues to pose significant challenges. In this study, a glucose-triggered gel with self-producing oxygen, photodynamic behavior, and analgesic properties is employed to address the aforementioned problems. The gel utilizes the cascade reaction of glucose oxidase and catalase to convert the excessive glucose in diabetic abscess tissue into oxygen, alleviate the hypoxia in the infected tissue, and ensure the occurrence of…

• NS
  Natural Science Foundation of Fujian Province

  Award: 2020J01748