articleNew England Journal of MedicineJun 1, 2025Closed access

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer

KSKerry S. CourneyaJLJanette L. VardyCJChristopher J. O’CallaghanSGSharlene GillCMChristine M. Friedenreich

University of Alberta · Concord Repatriation General Hospital · +19 more institutions

PubMed
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Abstract

Background

Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking.

Methods

In this phase 3, randomized trial conducted at 55 centers, we assigned patients with resected colon cancer who had completed adjuvant chemotherapy to participate in a structured exercise program (exercise group) or to receive health-education materials alone (health-education group) over a 3-year period. The primary end point was disease-free survival.

Citation impact

223
total citations
FWCI
175.11
Percentile
100%
References
40
Citations per year

Authors

27

Topics & keywords

Topics
Keywords
  • Medicine
  • Hazard ratio
  • Internal medicine
  • Colorectal cancer
  • Physical therapy
  • Clinical endpoint
  • Randomized controlled trial
  • Confidence interval
UN Sustainable Development Goals
  • Good health and well-being
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Funding