Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications

The nervous system precisely regulates physiological activities throughout the body, controlling not only muscle movement, sensory perception, cognition, and responses to external stimuli but also the immune system. In the tumor microenvironment (TME), neural components are important constituents that control the genesis, invasion, and metastasis of tumors by regulating the immune system. The nervous system modulates the tumor immune microenvironment (TIME) through localized control mechanisms (such as sensory, sympathetic, and parasympathetic innervation, as well as glial cell regulation) or via systemic adjustments, including circadian rhythm entrainment, stress modulation, and gut-brain axis regulation. To…

• NN
  National Natural Science Foundation of China

  Awards: 82173166, 81472475, 82372886
• CM
  Chongqing Medical University
• NS
  Natural Science Foundation of Chongqing

  Award: cstc2021jcyj